Ovarian Cancer Risk Markers (CA125/HE4)

An ovarian cancer test examines three key markers: CA-125 and HE4, which contribute to calculating the risk of ovarian malignancy algorithm (ROMA) score.

CA-125 refers to the protein present in both men's and women's blood. Elevated CA-125 levels may signal a health issue including a potential indication of ovarian cancer. This is because ovarian cancer cells can occasionally generate this protein. However, it is a relatively non-specific marker and cannot reliably differentiate cancer from other conditions. In contrast, HE4 is more precise. This protein is found in the cells lining the lungs and reproductive organs, including the ovaries. Increased HE4 levels can be detected in individuals with certain cancers, such as ovarian epithelial cancer.

ROMA is a numerical score calculated using CA-125 and HE4 levels to assess the likelihood of ovarian malignancy. When combined with other ovarian cancer tests, ROMA has been revealed to significantly improve detection sensitivity, unlike relying on CA-125 alone.

Importance of Ovarian Cancer Blood Test

This test is conducted like any routine blood test. Your clinician will ask you to expose one arm to locate a vein. A strap will be placed and fastened around the top arm to make veins more visible.

A needle is inserted into your vein, and a small blood sample is collected into tubes. Afterward, a small plaster will be attached to seal the site. You can take off the plaster after a few minutes.

How to Prepare: Since the test requires access to your arm, wearing loose clothing is recommended for convenience.

Contact or visit Sonoclinic today and explore the available diagnostic options for early detection of ovarian cancer.